Journal: Journal of Diabetes Research
Article Title: The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development
doi: 10.1155/2013/589451
Figure Lengend Snippet: Immune response and Th17 cell differentiation. Differences in Th17 polarisation were observed when controls were compared with T1D patients using microarray data. Genes of interest were analysed by qRT-PCR and were found to be upregulated in T1D patients. STAT3 and TGF-beta were chosen as representatives of Th17 cell differentiation. Microarray data demonstrated that CD4 was one of the most significantly upregulated molecules in T1D patients.
Article Snippet: (1) Immune response_Antigen presentation by MHCII (2) G protein signalling_Rac3 regulation pathway (3) Neurophysiological process_Olfactory transduction (4) Transcription_CREM signalling in testis (5) Dichloroethylene metabolism (6) Delta508-CFTR traffic/sorting endosome formation in CF (7) Immune response_Th17 cell differentiation (8) G-protein signalling_Regulation of CDC42 activity (9) Immune response_IL-22 signalling pathway (10) Development_BMP signalling , (1) Immune response_MIF-JAB1 signalling (2) Cytoskeleton remodeling_Fibronectin bindings integrins in cell motility (3) Translation_(L)-selenoaminoacids incorporation in proteins during translation (4) Regulation of lipid metabolism_Insulin regulation of glycogen metabolism (5) Glutathione metabolism (6) Development_Ligand-dependent activation of the ESR1/AP1 pathway (7) G protein signalling_Rac3 regulation pathway (8) Protein folding_Membrane trafficking and signal transduction of G-alpha (9) Neurophysiological process_Olfactory transduction (10) Dichloroethylene metabolism , (1) Cytoskeleton remodeling_CDC42 in cellular processes (2) Development_BMP signalling (3) Neurophysiological process_EphB receptors in dendritic spine morphogenesis and synaptogenesis (4) Development_Hedgehog signalling (5) Neolacto-series GSL Metabolism p.2 and p.3 (6) Neurophysiological process_Olfactory transduction (7) Atherosclerosis_Role of ZNF202 in regulation of expression of genes involved in Atherosclerosis (8) Dichloroethylene metabolism (9) Cytoskeleton remodeling_Neurofilaments (10) Triacylglycerol metabolism p.2.
Techniques: Cell Differentiation, Microarray, Quantitative RT-PCR
